A recent study investigated the effects of melatonin-free sleep support products that contain cannabinoids derived from hemp and other herbs. In the randomized, double-blind, placebo-controlled study, 620 adults seeking better sleep were given placebo or two different sleep formulas containing the same amount of CBD, CBN, and L-theanine, but differing in its THC. hop oil and valerian oil content. Formula A contained lower amounts of THC (0.35 mg) and higher amounts of GABA (150 mg), hop oil (75 mg) and valerian oil (75 mg) relative to formula B which had 0 .85 mg of THC, 125 mg of GABA, 20 mg of hop oil and 20 mg of valerian oil. The total duration of the study was five weeks, including four weeks of supplementation. Supplements were provided by MDBio and research was conducted by Radicle Science.
The primary outcome of the study was the change in the PROMIS Sleep Disturbance 8A scale, while the secondary outcomes were the changes in the PROMIS Anxiety 4a, PROMIS Stress 4a, PEG (pain, enjoyment, general activity) and the ‘World Health Organization (WHO). -5 Well-being index. The results showed that subjects taking Formula A experienced the greatest reduction in sleep disturbances, compared to placebo. Similarly, subjects taking Formula A also experienced a significant reduction in anxiety compared to placebo, as well as stress and a significant improvement in overall well-being. Formula B, on the other hand, had no significant impact on the study results.
According to the researchers, the benefits of the product can be attributed to the lower amount of THC, as well as the higher levels of GABA-modulating herbs, but these aspects were not directly investigated in the study. However, it deserves further investigation.
